IRF3 — Interferon regulatory factor 3
IRF3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IRF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ANKRD13D, ATP5ME, ATP5MJ, CAMTA1, CD2, CTDNEP1, DPP7, EIF3D +11 more | |
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | ACADM, AURKAIP1, BUD23, CBX3, CMC2, COPB1, DNAJA2, DYNC1LI1 +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Effector Maturation T cell maturation | ASF1A, BET1, CRYZ, DAXX, ECI2, EOMES, FNTA, LBH +10 more |
About the gene
| Chromosome | 19: 49659569-49665875 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation |
Function
Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.