ADGRF1 — Adhesion G protein-coupled receptor F1
ADGRF1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Oxidative Inflammatory Remodeling Inflammation | ACKR4, ADGRG6, AGRN, CFI, DAPP1, DUOXA1, DUSP4, HS3ST1 +11 more | View in SCUBA |
About the gene
| Synonyms | GPR110, hGPCR36, PGR19 |
|---|---|
| Chromosome | 6: 46997708-47042350 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Adhesion G-protein coupled receptor (aGPCR) for N- docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple to G(q), G(i) and G(12)/G(13) G proteins; additional evidence is however required to confirm this result in vivo. Involved in the development of neurons and cognitive function (By similarity). In liver, involved in fat accumulation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.