CFI — Complement factor I
CFI belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CFI's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Lysosomal Autophagy Program Stress | ABCD4, AKR1A1, ASPH, CD63, EBP, GNS, MAP1LC3A, MDH1 +4 more | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, DIPK2B, EGFL7, ELK3, ELN, FLT4, KCNN3 +10 more | View in SCUBA |
About the gene
| Synonyms | C3b-INA, FI, IF, KAF |
|---|---|
| Chromosome | 4: 109731008-109802150 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Complement pathway, Host-virus interaction, Immunity, Innate immunity |
Function
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.