DAPP1 — Dual adaptor of phosphotyrosine and 3-phosphoinositides 1
DAPP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DAPP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | CD53, CD81, CYTH1, DNAJC10, FAM3C, FCRLA, GPR18, HLA-DMA +11 more | View in SCUBA |
| CD4⁺ T cells | TCR signaling activation TCR/AP1/NFKb pathway | CNST, CORO1B, ECI1, FAAH2, FCMR, GPCPD1, KLHL24, MLLT3 +8 more | View in SCUBA |
| Macrophages | Immunoproteasome Induction Inflammatory | CBR1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2, NADK +12 more | View in SCUBA |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | AQP9, BACH1, CCR1, DUSP6, FYB1, IFI16, JAK2 | View in SCUBA |
About the gene
| Synonyms | BAM32 |
|---|---|
| Chromosome | 4: 99816827-99870190 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.