Oxidative Inflammatory Remodeling
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
This module is enriched in inf_colono and significantly upregulated in UC inflammation with reversal at remission. Hub genes include VNN1 (vanin-1, pantetheinase, oxidative stress/inflammation marker in IBD epithelium), XKR9 (phospholipid scramblase), AGRN (agrin, extracellular matrix), CFI (complement factor I), DAPP1 (dual adaptor for phosphoinositides), MMP14 (membrane-type matrix metalloproteinase), INSC (spindle orientation), DUOXA1 (dual oxidase maturation factor), SMOX (spermine oxidase, oxidative stress), DUSP4 (MAPK phosphatase, stress response), ACKR4 (atypical chemokine receptor). VNN1 is a well-established IBD epithelial inflammation marker. The module combines oxidative stress, complement, and ECM remodeling programs in inflamed colonocytes, consistent with a wound/inflammatory remodeling response.
Genes
Most correlated modules
- Epithelial Innate Immunity · correlation 0.91
- Basement Membrane Remodeling · correlation 0.87
- Hypoxia-Inflammatory Reprogramming · correlation 0.86
- Wound Regenerative Response · correlation 0.85
- Inflamed Barrier Remodeling · correlation 0.83
- IFN-γ Antiviral Response · correlation 0.83
- Inflammasome Pyroptosis · correlation 0.80
- IFN-gamma Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.