DUSP4 — Dual specificity phosphatase 4

DUSP4 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DUSP4's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Activated B cell B cell maturation	ARHGAP25, ARID3A, CFLAR, ENTPD1, MYO1F, PIK3R5, PLXNC1, PREX1 +6 more	View in SCUBA
CD4⁺ T cells	MAPK feedback signaling TCR/AP1/NFKb pathway	BACH1, DUSP16, E2F3, EPSTI1, MAT2B, PELI1, PIM2, SEC14L1 +2 more	View in SCUBA
CD8⁺ T cells	Cytotoxic Exhausted CD8 Exhaustion	CCL3, CD2BP2, CLEC2D, CTSD, GZMB, NDFIP2, PHLDA1, PRF1 +2 more	View in SCUBA
Gamma-delta T cells	AHR/NF-κB Survival Immune regulation	ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more
Goblet cells	DUOX2 Epithelial Inflammation Stress	AKAP13, BIRC3, DUOX2, DUOXA2, IL2RG, IL32, ISG15, RNF213 +1 more	View in SCUBA
Innate lymphoid cells	ILC Survival Residency Gut residency	ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, ENTPD1 +25 more	View in SCUBA
Macrophages	Osmotic Stress Response Stress	ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, EMP3, FURIN +25 more	View in SCUBA
Monocytes	SPP1+ Inflammatory Macrophage Inflammatory	DOCK4, FLT1, GPR137B, IL7R, INHBA, MMP14, NECTIN2, SDC2 +6 more	View in SCUBA

About the gene

Synonyms	HVH2, MKP-2, TYP
Chromosome	8: 29333064-29350684
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Molecular function	Hydrolase, Protein phosphatase

Function

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.