ADRA2B — Adrenoceptor alpha 2B
ADRA2B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADRA2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4, FOSL1 +9 more | View in SCUBA |
| Smooth muscle cells | Adrenergic Neuronal Transcripts Contractility | BCAS4, CCDC153, CLYBL, FBXL13, LSMEM2, PPP2R2B, PTPN3, RIMS3 +2 more | View in SCUBA |
About the gene
| Synonyms | ADRA2L1, ADRA2RL1, ADRARL1 |
|---|---|
| Chromosome | 2: 96112876-96116571 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.