CLYBL — Citramalyl-CoA lyase
CLYBL belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLYBL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Adrenergic Neuronal Transcripts Contractility | ADRA2B, BCAS4, CCDC153, FBXL13, LSMEM2, PPP2R2B, PTPN3, RIMS3 +2 more | View in SCUBA |
About the gene
| Synonyms | CLB |
|---|---|
| Chromosome | 13: 99606669-99909459 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Lyase, Transferase |
Function
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.