ADTRP — Androgen dependent TFPI regulating protein
ADTRP belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADTRP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | AKAP5, CDIP1, CDKN2A, CLEC7A, INPP1, MAP3K5, N4BP1, PBXIP1 +8 more | View in SCUBA |
About the gene
| Synonyms | AIG1L, C6orf105, dJ413H6.1 |
|---|---|
| Chromosome | 6: 11712054-11807046 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism |
Function
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.