BAK1 — BCL2 antagonist/killer 1
BAK1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BAK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon-stimulated genes Anti-viral | APOBEC3G, ARPC4, ARPC5L, BST2, DCTN3, ECH1, ETFB, FAM104A +14 more | View in SCUBA |
About the gene
| Synonyms | BAK, BCL2L7, CDN1 |
|---|---|
| Chromosome | 6: 33572547-33580293 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Apoptosis, Host-virus interaction |
Function
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.