FUT2 — Fucosyltransferase 2
FUT2 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FUT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Lysosomal Lipid Stress Stress | ADTRP, BAK1, BLOC1S1, CORO1B, CORO2A, DHCR24, GDPD3, GFER +14 more | View in SCUBA |
About the gene
| Synonyms | SE, Se2, SEC2, sej |
|---|---|
| Chromosome | 19: 48695971-48705951 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Blood group antigen, Glycosyltransferase, Transferase |
| Biological process | Lipid metabolism |
Function
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N- linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.