GFER — Growth factor, augmenter of liver regeneration
GFER belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GFER's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Lysosomal Lipid Stress Stress | ADTRP, BAK1, BLOC1S1, CORO1B, CORO2A, DHCR24, FUT2, GDPD3 +14 more | View in SCUBA |
About the gene
| Synonyms | ALR, ERV1, HERV1, HPO1, HPO2, HSS |
|---|---|
| Chromosome | 16: 1984193-1987749 |
| Predicted location | Intracellular, Secreted |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Growth factor, Oxidoreductase |
Function
FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May act as an autocrine hepatotrophic growth factor promoting liver regeneration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.