Lysosomal Lipid Stress
Gene co-expression module in Colonocytes
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include CORO2A (coronin, actin regulation), RAB1B (ER-Golgi trafficking), BAK1 (pro-apoptotic BCL2 family), TP53I3 (p53-inducible quinone oxidoreductase, oxidative stress), DHCR24 (cholesterol biosynthesis), MYO5B (myosin Vb, apical vesicle trafficking in enterocytes), FUT2 (fucosyltransferase, mucosal innate defense), SLC46A3 (lysosomal folate/lipid transporter), GPAT3 (glycerophospholipid synthesis), MMP15 (membrane-type MMP), GIPC1 (PDZ scaffold for MYO6/RAB). The very strong UC-specific inflammation signal (delta_UC=0.965, sig.) and enrichment in inf_colono suggest a stress-activated program. MYO5B loss causes microvillus inclusion disease, linking this to apical trafficking stress. The combination of lipid metabolism (DHCR24, GPAT3), lysosomal stress (SLC46A3), apoptotic priming (BAK1), and mucosal defense (FUT2) in inflamed colonocytes points to a lysosomal/lipid stress response program.
Genes
Most correlated modules
- Colonocyte Detoxification · correlation 0.94
- Epithelial Junction Integrity · correlation 0.91
- Endosomal Vesicle Trafficking · correlation 0.90
- Membrane Repair Response · correlation 0.89
- Inflammasome Activation · correlation 0.89
- Colonocyte Cytoskeletal Contractility · correlation 0.88
- Arp2/3 Actin Branching · correlation 0.88
- Senescent Surface Identity · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.