AGPAT3 — 1-acylglycerol-3-phosphate O-acyltransferase 3
AGPAT3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGPAT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD4 Lineage Identity T cell development | ACAA1, ASCC3, ATF2, KIFAP3, KXD1, NEK7, PARP4, PPM1A +6 more | View in SCUBA |
| Macrophages | Sphingolipid Membrane Homeostasis Lipid metabolism | ACER3, ARHGEF11, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8, FOXN2 +12 more | View in SCUBA |
About the gene
| Synonyms | LPAAT-gamma, LPAAT3, LPLAT3 |
|---|---|
| Chromosome | 21: 43865223-43987592 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. Has a preference for arachidonoyl-CoA as a donor (By similarity). Also has a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.