Sphingolipid Membrane Homeostasis
Gene co-expression module in Macrophages
| Category | Lipid metabolism |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include ACER3 (alkaline ceramidase 3, sphingolipid catabolism), ATP2A2 (SERCA2, ER calcium pump), TSPAN14 (tetraspanin regulating ADAM10 trafficking), DMXL2 (Rabconnectin-3, V-ATPase assembly/regulation), PAG1 (membrane raft signaling scaffold), OGA (O-GlcNAcase, glycosylation), C9orf72 (lysosomal/autophagy regulator), RHOT1 (mitochondrial Rho GTPase), and MAPK14 (p38). The module is enriched in mono_mac and combines sphingolipid metabolism (ACER3), ER membrane homeostasis (ATP2A2), and membrane trafficking/lysosomal regulation (DMXL2, C9orf72, TSPAN14). As a neighbor to M39 (endolysosomal trafficking), this module likely represents the lipid/membrane homeostasis arm of the same broader program, with emphasis on sphingolipid and ER membrane biology in monocyte-derived macrophages.
Genes
ACER3, AGPAT3, ARHGEF11, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8, FOXN2, GLUD1, MAPK14, OGA, PAG1, RHOT1, RNF149, SPG11, SUSD6, TBC1D2B, TBL1XR1, TSPAN14, ZDHHC17
Most correlated modules
- RNA Processing Transport · correlation 0.96
- Chromatin Regulatory Genes · correlation 0.96
- ER-Golgi Trafficking · correlation 0.96
- Myeloid Receptor Signaling · correlation 0.96
- Post-transcriptional Regulation · correlation 0.96
- RAB-mediated Trafficking · correlation 0.96
- Endolysosomal Trafficking · correlation 0.95
- Chromatin Remodeling · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.