ARHGEF11 — Rho guanine nucleotide exchange factor 11
ARHGEF11 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Sphingolipid Membrane Homeostasis Lipid metabolism | ACER3, AGPAT3, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8, FOXN2 +12 more | View in SCUBA |
About the gene
| Synonyms | GTRAP48, KIAA0380, PDZ-RHOGEF |
|---|---|
| Chromosome | 1: 156934840-157045742 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation, Guanine-nucleotide releasing factor |
Function
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.