ATP2A2 — ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ATP2A2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP2A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ER Calcium Stress Stress | ACOT7, CALU, ELOVL5, GTF2A2, LYAR, PSMD7, RCC2, UFD1 +1 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | BAMBI, C5AR2, CRISPLD2, CSNK1E, CTNNB1, DLC1, ETS2, F2RL3 +11 more | View in SCUBA |
| Gamma-delta T cells | ER Stress Response Stress | ATP1B3, BACH1, CPD, EIF2AK3, FAM118A, G3BP2, GRK5, HBP1 +13 more | |
| Goblet cells | ERAD ER Homeostasis Protein processing & ER | ARF4, C1orf122, DNAJB9, HERPUD1, JTB, LARP1B, PGM3, SELENOK +1 more | View in SCUBA |
| Macrophages | Sphingolipid Membrane Homeostasis Lipid metabolism | ACER3, AGPAT3, ARHGEF11, C9orf72, CMIP, DMXL2, DOCK8, FOXN2 +12 more | View in SCUBA |
| Smooth muscle cells | ER-Golgi Secretory Protein processing & ER | ARL2, BMP2, CD46, LAMB2, PLXND1, RNASEH2C, SPTB, YIF1A | View in SCUBA |
About the gene
| Synonyms | ATP2B, DAR, SERCA2 |
|---|---|
| Chromosome | 12: 110280756-110351093 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Calcium transport, Ion transport, Transport |
Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.