AHSP — Alpha hemoglobin stabilizing protein
AHSP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AHSP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ACOT9, AKIP1, BASP1, CASP1, CCR8, CD177, CSF2RB, CTSZ +13 more | View in SCUBA |
| Hematopoietic progenitor cells | Mature Erythrocyte Erythropoietic | ANK1, APOC1, CA1, CD36, CD40LG, CDH1, FAM178B, HBB +4 more |
About the gene
| Synonyms | EDRF, ERAF |
|---|---|
| Chromosome | 16: 31527900-31528803 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta- thalassemia
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.