HBB — Hemoglobin subunit beta
HBB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HBB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more | |
| Hematopoietic progenitor cells | Mature Erythrocyte Erythropoietic | AHSP, ANK1, APOC1, CA1, CD36, CD40LG, CDH1, FAM178B +4 more | |
| Mucosal-associated invariant T cell | NF-κB Effector Activation Inflammation | ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more |
About the gene
| Synonyms | beta-globin, CD113t-C |
|---|---|
| Chromosome | 11: 5225464-5229395 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Hypotensive agent, Vasoactive |
| Biological process | Oxygen transport, Transport |
Function
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.