APOC1 — Apolipoprotein C1
APOC1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | COL13A1+ Deep Fibroblast ECM production | BMPER, COL13A1, CSF1, GPR63, GPX3, GRIA3, HAAO, KLRF1 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Mature Erythrocyte Erythropoietic | AHSP, ANK1, CA1, CD36, CD40LG, CDH1, FAM178B, HBB +4 more | |
| Smooth muscle cells | Wnt-Hedgehog Niche Development | ADGRL3, CLMP, CMIP, EDNRB, HSD17B6, IRS1, LTBP3, NPNT +8 more | View in SCUBA |
About the gene
| Chromosome | 19: 44914247-44919349 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Metabolic proteins, Plasma proteins, Predicted secreted proteins |
| Biological process | Lipid transport, Transport |
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.