ALDH1A2 — Aldehyde dehydrogenase 1 family member A2
ALDH1A2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ALDH1A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ACSL1, CRK, INPP5A, LIMK2, NUP98, PIK3R5, PTPN12 +6 more |
About the gene
| Synonyms | RALDH2 |
|---|---|
| Chromosome | 15: 57953424-58497866 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all- trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.