APIP — APAF1 interacting protein
APIP belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APIP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, B4GALNT1, CAMK4, CCL5, CCNG2, CD247, CD3E, DCXR +17 more | View in SCUBA |
About the gene
| Synonyms | APIP2, CGI-29, Mmrp19 |
|---|---|
| Chromosome | 11: 34853094-34916379 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | Amino-acid biosynthesis, Apoptosis, Methionine biosynthesis |
Function
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.