Inflammasome Activation
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes FFAR4, P3H2, IL18, and APIP, all strongly enriched in inf_colono, define this module. IL18 is a canonical inflammasome output cytokine produced by colonocytes; APIP directly inhibits caspase-1 and pyroptosis. STK17A and BCL2L15 add pro-apoptotic/cell death regulation. S100A14 and S100A6 are calcium-binding proteins upregulated in inflamed epithelium. The module is significantly upregulated in UC inflammation (delta_inflammation_UC=0.926, sig.) and enriched in inflamed colonocytes across multiple genes. The moderate coherence reflects a mix of tight inflammasome genes and broader epithelial stress/structural genes (KRT8/18/19, CD24) co-expressed in the same inflamed colonocyte state.
Genes
Most correlated modules
- Inflamed Barrier Remodeling · correlation 0.89
- Lysosomal Lipid Stress · correlation 0.89
- Membrane Repair Response · correlation 0.88
- Arp2/3 Actin Branching · correlation 0.85
- Hypoxic Oxidative Stress · correlation 0.81
- Epithelial Innate Immunity · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.