CBR1 — Carbonyl reductase 1
CBR1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CBR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Carbohydrate Digestion/Detox Nutrient metabolism | CMBL, DDC, GSTA1, HADHB, KBTBD11, MAOA, PEBP1, SI +1 more | View in SCUBA |
| Gamma-delta T cells | Proteostasis/Chaperonin Protein processing & ER | BST2, CARD16, CCT3, CCT6A, DOK2, DYNLL1, HIKESHI, ME2 +13 more | |
| Macrophages | Immunoproteasome Induction Inflammatory | DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2, NADK +12 more | View in SCUBA |
About the gene
| Synonyms | CBR, SDR21C1 |
|---|---|
| Chromosome | 21: 36069941-36073166 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione- conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.