CD24 — CD24 molecule
CD24 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD24's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell Maturation B cell maturation | ANK3, ANTXR2, COL4A3, COL4A4, CSGALNACT1, ITM2C, PDCD4, PPP1R2C +3 more | View in SCUBA |
| Goblet cells | Actin Dynamics Cytoskeletal | ABRACL, CFL1, MYL12A, NDUFB4, NDUFS5, OCIAD2, PIN4, RTRAF +3 more | View in SCUBA |
| Lymphatic endothelial | DPP4+ Progenitor State migration & adhesion | ADAMTS6, DPP4, GSTM3, ISYNA1, PIK3C2G, SBSPON, TCTN3 | View in SCUBA |
| Neutrophils | Immature Neutrophil Granule Developmental | BPI, CCDC85B, CEACAM8, CPNE3, OLFM4, RETN, RGCC, SVIP |
About the gene
| Synonyms | CD24A |
|---|---|
| Chromosome | 6: 106969831-106975627 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Essential proteins, Predicted intracellular proteins |
Function
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin- like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.