APAF1 — Apoptotic peptidase activating factor 1
APAF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APAF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | DNA Damage Response Stress | ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L, EPB41 +19 more | View in SCUBA |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, ARFGEF1, ATF7IP, BLTP1, CEP350, FAR2, FBXW2, HIPK2 +5 more |
About the gene
| Synonyms | APAF-1, CED4 |
|---|---|
| Chromosome | 12: 98645290-98735433 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Apoptosis |
Function
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.