EPB41 — Erythrocyte membrane protein band 4.1
EPB41 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPB41's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory effector Immune regulation | C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EIF4E3, FYCO1, IL18R1 +9 more | View in SCUBA |
| Endothelial | Hypoxia Stress Response Stress | ABCA5, ALDH2, BAALC, CIRBP, EGLN3, FARP1, FTL, LRP5 +7 more | View in SCUBA |
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1 +16 more | |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, FBXO34, FGD6, GUCY1A1, ITGA6, MDFIC, NAV1 +13 more | View in SCUBA |
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immune Synapse Signaling TCR Signaling | APC, ARHGAP26, ASXL2, CD46, CPSF2, DOCK8, EEA1, EIF4G3 +21 more |
About the gene
| Synonyms | 4.1R, EL1 |
|---|---|
| Chromosome | 1: 28887091-29120046 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Actin-binding, Calmodulin-binding |
| Biological process | Cell cycle, Cell division, Mitosis, Transport |
Function
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.