DNA Damage Response
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 28 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes include RPRD2 (RNA Pol II CTD phosphatase regulator), APAF1 (apoptosome scaffold, intrinsic apoptosis), PTEN (PI3K/AKT tumor suppressor), ATR (DNA damage checkpoint kinase), CEP85L and CEP192 (centrosome assembly, mitotic entry), INO80 (chromatin remodeling ATPase), YTHDC2 (m6A RNA helicase), and SMG6 (nonsense-mediated decay). The module is highly mixed with weak coherence throughout. The strongest sub-theme is DNA damage response/checkpoint (ATR, APAF1, PTEN, INO80, SMG6). CEP192 enrichment in prolif_mac supports a cell cycle/DNA integrity link. No tight single program is identifiable; DNA damage response is the best-supported theme.
Genes
APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L, EPB41, GRK3, INO80, LPIN2, LRRK1, MDN1, PIP4K2A, PTEN, RABEP1, RPRD2, SMG6, STIM2, SYNJ1, TNRC18, TOGARAM1, UBAC2, YAF2, YTHDC2, ZNF33A, ZNF710
Most correlated modules
- Transcriptional Regulation · correlation 0.98
- Rho GTPase Signaling · correlation 0.98
- Chromatin Remodeling · correlation 0.98
- Post-transcriptional Regulation · correlation 0.96
- ER Stress Response · correlation 0.96
- MITF Lysosomal Program · correlation 0.95
- Rho GTPase Signaling · correlation 0.95
- Chromatin Epigenetic Regulation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.