CDC42SE2 — CDC42 small effector 2
CDC42SE2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC42SE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell quiescence regulation Immune regulation | CDKN1B, FOXP1, ICAM2, KRAS, MRPS6, MSL3, SERINC5, SLC5A3 +4 more | View in SCUBA |
| Enterocytes | STAT3/JNK signaling Inflammation | ETV6, KIAA0232, LRRC1, MAPK8, PDLIM5, PELI1, STAT3, STK24 | View in SCUBA |
| Gamma-delta T cells | IFN-gamma Receptor Signaling Inflammation | BORCS5, CCDC93, DHCR7, EML4, IFNGR1, PDE4B, PGRMC2, PLEKHA2 +3 more | |
| Innate lymphoid cells | Pre-mRNA Splicing RNA processing & translation | AAK1, CIB1, DDX46, HNRNPM, KRT10, KTN1, LARP7, LYRM2 +3 more | View in SCUBA |
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CENATAC, CEP192, CEP85L, EPB41 +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ABTB3, AOAH, ARID1B, ARID2, ATP8A1, ATXN1, BRAF, CCSER2 +13 more |
About the gene
| Synonyms | FLJ21967, SPEC2 |
|---|---|
| Chromosome | 5: 131245493-131398447 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell shape, Phagocytosis |
Function
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.