CENATAC — Centrosomal AT-AC splicing factor
CENATAC belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENATAC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CEP192, CEP85L, EPB41 +19 more | View in SCUBA |
About the gene
| Synonyms | CCDC84, DLNB14 |
|---|---|
| Chromosome | 11: 118998138-119015793 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Biological process | mRNA processing, mRNA splicing |
Function
Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype. Negative regulator of centrosome duplication. Constrains centriole number by modulating the degradation of the centrosome- duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.