APH1B — Aph-1 homolog B, gamma-secretase subunit
APH1B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APH1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Inflammation | ANKS1A, ARL4A, BZW2, C1orf21, CCNG1, CCNG2, DNPH1, EBPL +9 more | View in SCUBA |
About the gene
| Synonyms | APH-1B, DKFZp564D0372, PSFL |
|---|---|
| Chromosome | 15: 63276018-63309126 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Notch signaling pathway |
Function
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.