BZW2 — Basic leucine zipper and W2 domains 2
BZW2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BZW2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ABCF1, BCL2A1, BUD23, CALR, CEBPZ, DDX21, DENND4A, GNL3 +21 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Inflammation | ANKS1A, APH1B, ARL4A, C1orf21, CCNG1, CCNG2, DNPH1, EBPL +9 more | View in SCUBA |
| Goblet cells | Mitochondrial Homeostasis Mitochondrial & OxPhos | COX5A, MPST, PEBP1, PHB2, PPIA, PRDX2, SNRPE | View in SCUBA |
| Hematopoietic progenitor cells | Biosynthetic Housekeeping Housekeeping | CHST12, CREG1, EEF1B2, FBL, HNRNPA1, HSP90AB1, IMPDH2, LDHB +7 more | |
| Smooth muscle cells | Lysosomal-secretory processing Protein processing & ER | COPZ1, CTSL, LAMP1, PIGT, PLOD2, PRMT2, RGS9, RPN2 +5 more | View in SCUBA |
About the gene
| Synonyms | 5MP1, HSPC028, MST017, MSTP017 |
|---|---|
| Chromosome | 7: 16646131-16706523 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Translation regulation |
Function
Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function. Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C- binding dependent manner.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.