DNPH1 — 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DNPH1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNPH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, BATF, CTLA4, GBP2, IL2RA, NAMPT, NDFIP2, NINJ2 +6 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Inflammation | ANKS1A, APH1B, ARL4A, BZW2, C1orf21, CCNG1, CCNG2, EBPL +9 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DUSP23, ETFB +20 more | |
| Hematopoietic progenitor cells | Nucleotide Metabolism Housekeeping | DCTPP1, EIF4EBP1, FKBP4, GCSH, METTL26, MRPL12, NHP2, NME4 +2 more | |
| Innate lymphoid cells | ILC1 Cytoskeletal Metabolic Cytoskeleton & motility | ATP5F1B, ATXN10, CCT7, CD82, GADD45GIP1, HMGA1, MEA1, MTCH2 +14 more | View in SCUBA |
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 more | View in SCUBA |
| Monocytes | Complement C1q Macrophage Innate immunity | ACP2, C1QA, C1QB, C1QC, CLIC2, GFRA2, ITGA9, NR1H3 +4 more | View in SCUBA |
About the gene
| Synonyms | C6orf108, dJ330M21.3, rcl |
|---|---|
| Chromosome | 6: 43225629-43229481 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Glycosidase, Hydrolase |
| Biological process | Nucleotide metabolism |
Function
Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.