Inflammatory Stress Response
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include APH1B (gamma-secretase component), GNG12 (G-protein gamma subunit), CCNG2 and CCNG1 (cyclins G2 and G1, cell cycle inhibitory cyclins), SNCA (alpha-synuclein), SPHK1 (sphingosine kinase 1, pro-survival/inflammatory lipid signaling), SIRPA (inhibitory immune receptor), KRT18 (epithelial keratin — possible contamination marker), TMED3 (COPI vesicle trafficking). The module is strongly upregulated in both UC and CD inflammation and reverses in remission. CCNG1/CCNG2 are stress-responsive cyclins often induced by p53. SPHK1 is a key inflammatory mediator. The combination of SPHK1, CCNG1/2, SIRPA, and GNG12 suggests an inflammatory signaling response. KRT18 may indicate minor epithelial contamination but is a single gene. The dominant signal is inflammatory/stress signaling in endothelial cells during IBD.
Genes
ANKS1A, APH1B, ARL4A, BZW2, C1orf21, CCNG1, CCNG2, DNPH1, EBPL, GNG12, KLHL3, KRT18, MAP7D3, SAT2, SIRPA, SNCA, SPHK1, TMED3
Most correlated modules
- Angiogenic Metabolic Adaptation · correlation 0.93
- Endothelial Cell Migration · correlation 0.84
- Lysosomal Autophagy Program · correlation 0.83
- Oxidative Phosphorylation · correlation 0.81
- Inflammatory ECM Remodeling · correlation 0.81
- Venous EC Identity · correlation 0.79
- Leukocyte Recruitment Signaling · correlation 0.78
- Translation Elongation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.