API5 — Apoptosis inhibitor 5
API5 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
API5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Chromatin & Splicing DNA/chromatin regulation | ACIN1, ADAR, BAZ2A, CDC73, CDK12, COPA, FUBP1, KAT7 +11 more |
About the gene
| Synonyms | AAC-11, AAC11, API5L1 |
|---|---|
| Chromosome | 11: 43311963-43344529 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.