COPA — COPI coat complex subunit alpha
COPA belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | GIMAP survival Immune regulation | ABLIM1, AKT3, ANKRD13D, ARL4C, C16orf54, CA5B, CRBN, DYNLT1 +16 more | View in SCUBA |
| Gamma-delta T cells | Wnt-STAT3 Signaling TCR Signaling | BTBD1, CTNNB1, DHX9, EZR, HECTD1, NUP153, PAFAH1B1, SPRTN +5 more | |
| Goblet cells | Protein trafficking & glycosylation Mucus production & secretion | COPB1, COPB2, COPG1, EDEM3, FAM114A1, GALNT3, GALNT7, TM9SF2 +1 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, DYNC1H1, HNRNPC, JOSD1, LCP2, LRRFIP1 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin & Splicing DNA/chromatin regulation | ACIN1, ADAR, API5, BAZ2A, CDC73, CDK12, FUBP1, KAT7 +11 more |
About the gene
| Synonyms | HEP-COP |
|---|---|
| Chromosome | 1: 160288594-160343566 |
| Predicted location | Intracellular, Secreted |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hormone |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.