SCUBA

FUBP1 — Far upstream element binding protein 1

FUBP1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FUBP1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsEpigenetic regulation
DNA/chromatin regulation		AFF4, ARID1B, CTSA, DGKH, JARID2, PDCD6, SYNCRIP, TET2 +6 moreView in SCUBA
CD8⁺ T cellsRNA Processing Mixed
RNA processing & translation		AIP, CALM1, EZR, HNRNPA2B1, HNRNPH3, LCP1, LRRFIP1, MOB1A +8 moreView in SCUBA
EndothelialmRNA Splicing
RNA processing & translation		DIAPH1, EIF4A3, GLRX5, HNRNPA2B1, HNRNPA3, HNRNPD, KHDRBS1, MAGOH +8 moreView in SCUBA
Gamma-delta T cellsPost-transcriptional RNA Regulation
RNA processing & translation		CCNG1, DHX15, HNRNPA3, IPO7, ITPR2, OSBPL3, PLEKHB2, SP140
Innate lymphoid cellsER-Golgi Trafficking
Protein processing & ER		ATP2B1, ATP6V1D, CAPZA2, CGGBP1, CNOT4, COPS5, CRIPT, CSTB +15 moreView in SCUBA
MacrophagesTranscriptional Regulation
Housekeeping		CCSER2, CUX1, ECPAS, EPB41L3, GATAD2A, GNA12, LRRFIP2, MED15 +10 moreView in SCUBA
Mucosal-associated invariant T cellChromatin & Splicing
DNA/chromatin regulation		ACIN1, ADAR, API5, BAZ2A, CDC73, CDK12, COPA, KAT7 +11 more

About the gene

SynonymsFBP, FUBP
Chromosome1: 77944055-77979110
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Plasma proteins, Predicted intracellular proteins
Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Function

Regulates MYC expression by binding to a single-stranded far- upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.