Chromatin & Splicing
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes KAT7 (histone acetyltransferase), BAZ2A (chromatin remodeling), CDC73 (PAF1 complex), RAD21 (cohesin), CDK12 (transcription-coupled repair) define a chromatin/transcription regulation program. Multiple RNA splicing factors (SNRNP200, RBM25, RBM33, SREK1, ADAR, TCERG1, ACIN1) co-cluster, consistent with co-transcriptional splicing coupling. The module reflects a general transcription-coupled chromatin and RNA processing housekeeping program broadly expressed (uniform, ~30% cells). Neighbor modules M95 and M92 also feature chromatin remodelers and RNA processors, supporting a shared housekeeping transcription program neighborhood.
Genes
ACIN1, ADAR, API5, BAZ2A, CDC73, CDK12, COPA, FUBP1, KAT7, LATS1, QRICH1, RAD21, RBM25, RBM33, SNRNP200, SREK1, TCERG1, TPP2, ZNF267, ZNF460
Most correlated modules
- Chromatin Remodeling · correlation 0.89
- RNA Splicing Processing · correlation 0.85
- Epigenetic Maintenance · correlation 0.84
- STAT3 Cytokine Signaling · correlation 0.84
- Vesicle Membrane Trafficking · correlation 0.83
- Lymphocyte Migration · correlation 0.83
- Chromatin Epigenetic Regulation · correlation 0.81
- Histone Modification · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.