ARL4D — ADP ribosylation factor like GTPase 4D
ARL4D belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARL4D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Notch signaling Intercellular communication | ARRDC2, HES1, ICOSLG, IRS2, KLF4, MXI1, NRARP, PMEPA1 +2 more | View in SCUBA |
| CD4⁺ T cells | Hypoxia metabolic stress Stress | ARG2, AXIN2, BNIP3, CITED4, CNKSR2, GCA, GSTM3, ID3 +13 more | View in SCUBA |
About the gene
| Synonyms | ARF4L |
|---|---|
| Chromosome | 17: 43398993-43401137 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.