Notch signaling
Gene co-expression module in CD19⁺ B cells
| Category | Intercellular communication |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Strongly Notch-signaling / activation module: HES1, NRARP, HEY-family-related NRARP, KLF4, IRS2, PMEPA1 (TGFb target), ICOSLG (costimulation). HES1 and NRARP are canonical Notch targets; this reflects a Notch/co-stimulatory activation state in B cells. Core coherence.
Genes
ARL4D, ARRDC2, HES1, ICOSLG, IRS2, KLF4, MXI1, NRARP, PMEPA1, PRR7, ZNF669
Most correlated modules
- Plasma cell secretory · correlation 0.86
- Hypoxia/metabolic stress · correlation 0.85
- B cell quiescence · correlation 0.76
- Immediate early response · correlation 0.76
- Naive B cell · correlation 0.72
- NFkB/MAPK activation · correlation 0.72
- TGF-beta/differentiation · correlation 0.69
- B cell identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.