MXI1 — MAX interactor 1, dimerization protein
MXI1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MXI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Notch signaling Intercellular communication | ARL4D, ARRDC2, HES1, ICOSLG, IRS2, KLF4, NRARP, PMEPA1 +2 more | View in SCUBA |
| Enterocytes | Mature enterocyte differentiation Absorption | ABCC2, ACSF2, AOC1, CDC14A, CEP350, EEPD1, EPS8L2, GRAMD1C +5 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing & Trafficking RNA processing & translation | ARF1, ARL6IP1, ARRDC2, B3GNT2, C17orf49, CCDC12, CWC15, DDX39A +19 more | |
| Mucosal-associated invariant T cell | Transcriptional Repression Immune regulation | ANKRD11, CMIP, NR3C1, PELI2, PROSER1, RB1CC1, RCOR1, RFTN1 +7 more | |
| Smooth muscle cells | Vascular Matrix Secretion ECM remodeling | ARPC1B, BGN, CALHM2, HSPB7, MGP, RAB13, TRIM47 | View in SCUBA |
About the gene
| Synonyms | bHLHc11, MAD2, MXD2, MXI |
|---|---|
| Chromosome | 10: 110207605-110287365 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.