IRS2 — Insulin receptor substrate 2
IRS2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IRS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Notch signaling Intercellular communication | ARL4D, ARRDC2, HES1, ICOSLG, KLF4, MXI1, NRARP, PMEPA1 +2 more | View in SCUBA |
| CD4⁺ T cells | Glucocorticoid Immunoregulation Immune regulation | AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, JUND, KLF6 +11 more | View in SCUBA |
| Gamma-delta T cells | ER Stress Response Stress | ATP1B3, ATP2A2, BACH1, CPD, EIF2AK3, FAM118A, G3BP2, GRK5 +13 more | |
| Goblet cells | Hypoxia Metabolic Stress Stress | ADGRE5, ANKRD37, ARL4A, FBXO32, KLF2, LRRFIP1, SKIL, TENT5A | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Activation Immune regulation | BCL3, FURIN, GTF3C1, IRAK1, ISCA1, PITHD1, PRELID3B, RABGGTB +3 more | |
| Natural Killer cells | TGF-β Antagonism Immune regulation | IFRD1, MOB3A, RBM39, SBDS, SMAD7, SRSF5, STK17B, ZBTB1 +1 more | View in SCUBA |
| Smooth muscle cells | BMP/TGF-beta response Activation | APBB2, GLS, ID1, ID2, KLF10, RND3, SEC11C, SIPA1L2 +1 more | View in SCUBA |
About the gene
| Chromosome | 13: 109752695-109786583 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transducer |
Function
Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2. Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta- catenin signaling pathway through suppression of DVL2 autophagy- mediated degradation leading to cell proliferation. Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase. In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.