ATP6V0D2 — ATPase H+ transporting V0 subunit d2
ATP6V0D2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V0D2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | A4GALT, ACP5, ASB2, ASMTL, BID, CFP, CPOX, CYB561A3 +12 more | View in SCUBA |
About the gene
| Synonyms | ATP6D2, FLJ38708, VMA6 |
|---|---|
| Chromosome | 8: 85987323-86154225 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.