A4GALT — Alpha 1,4-galactosyltransferase (P blood group)
A4GALT belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
A4GALT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Interferon Response Inflammatory | ABCA1, ABHD17C, BASP1, CCL7, CLEC2B, IFI16, IFI6, PLSCR1 +5 more | View in SCUBA |
| Lymphatic endothelial | Apoptosis Immune Regulation Immune regulation | CFLAR, COX17, GRINA, MPZL1, NINJ1, OPTN, PAWR, RCN1 +2 more | View in SCUBA |
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX, CYB561A3 +12 more | View in SCUBA |
About the gene
| Synonyms | A14GALT, Gb3S, P(k), P1 |
|---|---|
| Chromosome | 22: 42692121-42721298 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism |
Function
Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P. (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.