BID — BH3 interacting domain death agonist
BID belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BID's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, CFP, CPOX, CYB561A3 +12 more | View in SCUBA |
| Monocytes | Monocyte-Macrophage Differentiation Developmental | ADGRE2, ADGRE3, CYSLTR2, FAM110A, HES4, MARCKSL1, NRARP, PRELID1 +4 more | View in SCUBA |
| Neutrophils | NF-κB Inflammatory Transcription Inflammatory | C9orf72, DENND5A, ELL2, ETF1, N4BP1, NFE2L2, NFKB1, OXSR1 +10 more |
About the gene
| Chromosome | 22: 17734138-17774770 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Induces caspases and apoptosis. Counters the protective effect of BCL2 (By similarity). Induces caspase activation and apoptosis. Allows the release of cytochrome c. Induces ICE-like proteases and apoptosis. Induces ICE-like proteases and apoptosis. Does not induce apoptosis. Induces ICE-like proteases and apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.