MMP-driven ECM Remodeling
Gene co-expression module in Macrophages
| Category | ECM remodeling |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include RAB9A (late endosome/lysosome vesicle trafficking), MMP1 (collagenase-1, ECM remodeling, 4.9x mono_mac), MMP10 (stromelysin-2, ECM remodeling, 12.9x mono_mac), ELK1 (ETS transcription factor, MAPK target), FABP4 (fatty acid binding protein 4, lipid metabolism in macrophages), ACP5 (TRAP/tartrate-resistant acid phosphatase, marker of activated macrophages and osteoclasts), NKG7 (natural killer granule protein 7, cytotoxic/activated immune cells), CFP (properdin, complement pathway), GLO1 (glyoxalase I, methylglyoxal detoxification). MMP1+MMP10 are the strongest functional anchors pointing to ECM remodeling. ACP5 marks activated tissue-remodeling macrophages. The module represents a tissue-remodeling macrophage state with MMP-driven matrix degradation.
Genes
A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX, CYB561A3, ELK1, FABP4, GLO1, H2AC25, HIC1, HMG20B, HMGB3, MMP1, MMP10, NKG7, RAB9A, TMEM138
Most correlated modules
- NRF2 Oxidative Stress · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.