ACP5 — Acid phosphatase 5, tartrate resistant

ACP5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ACP5's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Inflammatory activation Immune regulation	B2M, CALCOCO1, CCNG2, CHST11, CORO1A, HLA-A, IL32, PITPNM2 +10 more	View in SCUBA
CD8⁺ T cells	Terminal Exhaustion Exhaustion	CARD16, CASP1, CD2, CD247, CD8A, CD8B, CHST12, CXCR6 +6 more	View in SCUBA
Fibroblasts	BMP-Wnt Fibroblast Program Developmental	BMP5, CTSD, CTXND1, DAAM2, ENPP6, GMFG, TBC1D2B, TBX2	View in SCUBA
Gamma-delta T cells	Immature T Cell T cell maturation	A1BG, CD38, CD7, ID3, ITM2C, MZB1, NCF1, NUDT14 +7 more
Macrophages	MMP-driven ECM Remodeling ECM remodeling	A4GALT, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX, CYB561A3 +12 more	View in SCUBA
Monocytes	Tissue-destructive Macrophage Lysosomal & pahgocytosis	ANKH, BCAT1, ENG, FABP5, ID3, IL10, KIFC3, LDLRAD4 +7 more	View in SCUBA
Natural Killer cells	Resident NK program Gut residency	CDH17, CHCHD10, CKLF, ID3, KRT81, KRT86, NEDD9, RGL4 +2 more	View in SCUBA

About the gene

Synonyms	HPAP, TRAcP, TRAP
Chromosome	19: 11574653-11579993
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Hydrolase

Function

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T- cell leukemias

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.