CYB561A3 — Cytochrome b561 family member A3
CYB561A3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYB561A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell activation signaling B cell maturation | CD180, DAAM1, ETS1, LIMD2, STX7, TERF2IP, UCP2, ZNF106 | View in SCUBA |
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX +12 more | View in SCUBA |
About the gene
| Synonyms | CYBASC3 |
|---|---|
| Chromosome | 11: 61348754-61362283 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase, Translocase |
| Biological process | Electron transport, Transport |
Function
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.