BROX — BRO1 domain and CAAX motif containing
BROX belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BROX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA repair/replication DNA/chromatin regulation | ACAP2, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB, KMT2C +4 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Regulation Lysosomal & pahgocytosis | ADIPOR1, ARL8A, ATOSB, BCL10, CCR1, CEBPB, CHMP2B, CHP1 +22 more | View in SCUBA |
About the gene
| Synonyms | C1orf58, FLJ32421 |
|---|---|
| Chromosome | 1: 222712553-222735196 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.