Autophagy Lysosomal Regulation
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 31 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 31 genes have a known function matching the annotation |
Why this annotation
Hub genes include MAP1LC3B (LC3B, canonical autophagy marker), ARL8A (ARL8A, lysosome positioning/motility), CEBPB (C/EBPβ, master myeloid/macrophage TF), WDFY1 (FYVE domain, early endosome), CHMP2B (ESCRT-III, multivesicular body), RRAGC (Rag GTPase C, mTORC1 lysosomal activation), LAPTM4A (lysosomal transmembrane), BCL10 (NF-κB/CARD signaling), CCR1 (CC chemokine receptor 1, monocyte/macrophage), SLFN5 (Schlafen 5, interferon-induced), METRNL (meteorin-like, anti-inflammatory cytokine), TGIF1 (TGF-β signaling repressor). The autophagy-lysosomal pathway is the dominant theme: MAP1LC3B, ARL8A, CHMP2B, RRAGC, WDFY1, LAPTM4A. CEBPB and CCR1 confirm macrophage identity. This module represents autophagy/lysosomal regulation in monocyte-derived macrophages.
Genes
ADIPOR1, ARL8A, ATOSB, BCL10, BROX, CCR1, CEBPB, CHMP2B, CHP1, GTPBP2, LAPTM4A, LEPROT, MAP1LC3B, MCFD2, METRNL, OSGIN2, PRXL2C, RAP2C, RRAGC, SARAF, SDCBP, SGK3, SLC30A1, SLC31A2, SLFN5, STARD3NL, TGIF1, TMEM167B, UBALD2, WBP2, WDFY1
Most correlated modules
- Actin Cytoskeleton Organization · correlation 0.96
- Phagocytic Endolysosomal · correlation 0.96
- Golgi-Endosome Trafficking · correlation 0.94
- Macrophage Endocytic Signaling · correlation 0.94
- Monocyte Innate Signaling · correlation 0.93
- ER Protein Processing · correlation 0.93
- RAS-MAPK Signaling · correlation 0.91
- Transcriptional Elongation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.